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Trazodone is used to treat depression. Trazodone is in a class of medications called serotonin modulators. It works by increasing the amount of serotonin, a natural substance in the brain that helps maintain mental balance.

Usage directions

Trazodone comes as a tablet to take by mouth. It is usually taken with a meal or light snack two or more times a day. To help you remember to take trazodone, take it around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take trazodone exactly as directed. Do not take more or less of it, take it more often, or take it for a longer time than prescribed by your doctor.

Your doctor may start you on a low dose of trazodone and gradually increase your dose, not more than once every 3 to 4 days. Your doctor may decrease your dose once your condition is controlled.

Trazodone controls depression, but does not cure it. It may take 2 weeks or longer before you feel the full benefit of trazodone. Continue to take trazodone even if you feel well. Do not stop taking trazodone without talking to your doctor. Your doctor will probably decrease your dose gradually.

Other uses

Trazodone is also sometimes used to treat insomnia and schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions); anxiety (excessive worry). Trazodone is also sometimes used to control abnormal, uncontrollable movements that may be experienced as side effects of other medications. Talk to your doctor about the possible risks of using this medication for your condition.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Special precautions

Before taking trazodone,

• tell your doctor and pharmacist if you are allergic to trazodone or any other medications.
• tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: anticoagulants ('blood thinners') such as warfarin (Coumadin); antidepressants, antifungal medications such as fluconazole (Diflucan), itraconazole (Sporanox), and ketoconazole (Nizoral); cimetidine (Tagamet); clarithromycin (Biaxin, Prevpac); cyclosporine (Neoral, Sandimmune); danazol (Danocrine); delaviridine (Rescriptor); dexamethasone (Decadron); digoxin (Digitek, Lanoxin, Lanoxicaps); diltiazem (Cardizem, Dilacor, Tiazac); erythromycin (E.E.S., E-Mycin, Erythrocin); HIV protease inhibitors such as indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir), and saquinavir (Fortovase, Invirase); isoniazid (INH, Nydrazid); medications for allergies, cough or colds; medications for anxiety, high blood pressure, irregular heartbeat, mental illness or pain; medication for seizures such as carbamazepine (Tegretol), ethosuximide (Zarontin), phenobarbital (Luminal, Solfoton), and phenytoin (Dilantin); metronidazole (Flagyl); muscle relaxants; nefazodone; oral contraceptives (birth control pills); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane); sedatives; selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine (Prozac, Sarafem) and fluvoxamine (Luvox); sleeping pills; tranquilizers; troleandomycin (TAO); verapamil (Calan, Isoptin, Verelan); or zafirlukast (Accolate). Also, tell your doctor or pharmacist if you are taking the following medications, called MAO inhibitors, or if you have stopped taking them within the past 2 weeks: isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
• tell your doctor what herbal products you are taking, especially St. John's wort.
• tell your doctor if you are being treated with electroshock therapy (procedure in which small electric shocks are administered to the brain to treat certain mental illnesses) and if you have or have ever had cancer; a heart attack, irregular heart beat; high blood pressure; human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS); low white blood cell count; or heart disease.
• tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking trazodone, call your doctor.
• if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking trazodone.
• you should know that trazodone may make you drowsy and affect your judgment. Do not drive a car or operate machinery until you know how this medication affects you. If drowsiness is a problem, ask your doctor about taking part of your dose at bedtime.
• ask your doctor about the safe use of alcoholic beverages while you are taking trazodone. Alcohol can make the side effects from trazodone worse.
• you should know that trazodone may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.

Food limitations and special diet when taking Trazodone

Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medicine.

Missed dose

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Possible side effects

Trazodone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• headache or heaviness in head
• nausea
• vomiting
• bad taste in mouth
• stomach pain
• diarrhea
• constipation
• changes in appetite or weight
• weakness or tiredness
• nervousness
• decreased ability to concentrate or remember things
• confusion
• nightmares
• muscle pain
• dry mouth
• sweating
• blurred vision
• tired, red, or itchy eyes
• ringing in ears

Some side effects can be serious. If you experience any of the following symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately:

• chest pain
• fast, pounding, or irregular heartbeat
• shortness of breath
• fever, sore throat, chills, or other signs of infection
• hives
• skin rash
• itching
• difficulty breathing or swallowing
• swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
• hoarseness
• decreased coordination
• uncontrollable shaking of a part of the body
• numbness, burning, or tingling in the arms, legs, hands, or feet
• dizziness or lightheadedness
• fainting
• painful erection that lasts longer than normal

Trazodone may cause painful, long lasting erections in males. In some cases emergency and/or surgical treatment has been required and, in some of these cases, permanent damage has occurred. Talk to your doctor about the risk of taking trazodone.

Trazodone may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

Storage and disposal of Trazodone

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

Emergency/overdose

In case of overdose, call your local poison control center. If the victim has collapsed or is not breathing, call local emergency services.

Symptoms of overdose may include:

• vomiting
• drowsiness
• changes in heartbeat
• seizures
• difficulty breathing
• painful erection that does not go away

Other important information

Keep all appointments with your doctor.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Disclaimer

We provide only general information about Desyrel which does not cover all possible drug integrations, directions or precautions. Information at our website cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with his health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

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